The top left ones are single-use needles from the 1950s with various lengths and gauges. They are also required for catheter-introduced surgical procedures in deep anatomical locations.įigure 1 shows three generations of needles. Micro-silicon-based needles, so small that they don’t trigger pain nerves are being developed, however, these systems cannot deliver intravenous or bolus injections so hypodermic needles, with or without syringes, are likely to be with us for a long time. Looking to the future of the parenteral administration of medicines and vaccines, it’s likely that there will be increasing use of direct percutaneous absorption, especially for children. The basic design has remained unchanged though interchangeable parts and the use of plastic resulted in the almost universal use of disposable syringes and needles since the mid-1950s. Charles Pravaz, in France, administered coagulant to sheep in 1853, but it seems that Alexander Wood in Edinburgh combined a functional syringe with a hypodermic needle in the same year, to inject morphine into humans and probably should be credited with inventing the technique. A syringe has three elements, the barrel (glass, plastic or metal), the plunger and the piston which may be of rubber, mineral, metal or synthetic material but in early examples waxed linen tape or asbestos was wound on a reel to obtain a watertight seal. The bevelled point is cut and ground, and then the hub is added with its variety of fittings and locks. This was then drawn through increasingly narrower dies whilst maintaining the patency of the needle. The first hypodermic needle was probably made by Francis Rynd in Dublin in 1844, using the technology of annealing the edges of a folded flat strip of steel to make a tube. The disastrous consequences of these experiments delayed the use of injections for 200 years. By 1660 Drs Major and Esholttz used this method on humans with similar fatal results due to ignorance of suitable dosage and the need for sterilising utensils and the infusion. Christopher Wren (better known as an architect than for his medical training), used a ‘cut-down’ technique to intravenously inject dogs with poppy sap through goose quill canulae. In 1650, Pascal’s experimental work in hydraulics stimulated him to invent the first modern syringe which allowed the infusion of medicines. Simple piston syringes for delivering ointments and creams for medical use were described by Galen (129-200 CE) and an Egyptian, Ammar bin Ali al-Mawsili, reported using glass tubes to apply suction for cataract extraction from about 900 CE. Their origins are found in Greek and Roman literature where there are descriptions of hollow reeds for the ritual of anointing the body with oil, and as musical instruments using a plunger to alter the pitch. Syringes were invented long before hypodermic needles.
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